Description
Biochem/physiol Actions Nucleoside analog that has antifungal activities. 5-FC is deaminated by cytosine deaminase to product 5-fluorouracil, resulting in RNA miscoding. 5-Fluorocytosine inhibits DNA and RNA synthesis and interferes with ribosomal protein synthesis.
Properties
mp 298-300 °C （dec.）（lit.）
storage temp. 2-8°C
Safety
Personal Protective Equipment Eyeshields, Gloves, type N95 （US）, type P1 （EN143） respirator filter
Safety Statements 22-24/25
WGK Germany 2
RTECS HA6040000
References
reference Waldorf, A.R., and Polak, A., Mechanisms of action of 5-fluorocytosine. Antimicrob. Agents Chemother. 23, 79-85, （1983）
Diasio, R.B., et al., Mode of action of 5-fluorocytosine. Biochem. Pharmacol. 27, 703-7, （1978）
Merck Merck 13,4151
Beilstein Beil. 25,IV,3688
Aldrich MSDS 1, 959:D / Corp MSDS 1 （1）, 1705:D / FT-NMR 1 （3）, 383:C / RegBook 1 （2）, 2579:B / Sax 6, 1435 / Sigma FT-IR 1 （1）, 996:A / Structure Index 1, 408:C:1
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